Title |
Detection and localization of surgically resectable cancers with a multi-analyte blood test
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Published in |
Science, January 2018
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DOI | 10.1126/science.aar3247 |
Pubmed ID | |
Authors |
Joshua D Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Ludmila Danilova, Christopher Douville, Ammar A Javed, Fay Wong, Austin Mattox, Ralph H Hruban, Christopher L Wolfgang, Michael G Goggins, Marco Dal Molin, Tian-Li Wang, Richard Roden, Alison P Klein, Janine Ptak, Lisa Dobbyn, Joy Schaefer, Natalie Silliman, Maria Popoli, Joshua T Vogelstein, James D Browne, Robert E Schoen, Randall E Brand, Jeanne Tie, Peter Gibbs, Hui-Li Wong, Aaron S Mansfield, Jin Jen, Samir M Hanash, Massimo Falconi, Peter J Allen, Shibin Zhou, Chetan Bettegowda, Luis A Diaz, Cristian Tomasetti, Kenneth W Kinzler, Bert Vogelstein, Anne Marie Lennon, Nickolas Papadopoulos |
Abstract |
Earlier detection is key to reducing cancer deaths. Here we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1,005 patients with non-metastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69% to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was > 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 317 | 25% |
United Kingdom | 96 | 8% |
Spain | 66 | 5% |
France | 39 | 3% |
Canada | 28 | 2% |
Japan | 28 | 2% |
Australia | 23 | 2% |
Saudi Arabia | 22 | 2% |
Poland | 17 | 1% |
Other | 186 | 15% |
Unknown | 450 | 35% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 774 | 61% |
Scientists | 336 | 26% |
Practitioners (doctors, other healthcare professionals) | 134 | 11% |
Science communicators (journalists, bloggers, editors) | 28 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2521 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 495 | 20% |
Student > Ph. D. Student | 384 | 15% |
Student > Master | 216 | 9% |
Student > Bachelor | 210 | 8% |
Other | 171 | 7% |
Other | 408 | 16% |
Unknown | 637 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 593 | 24% |
Medicine and Dentistry | 434 | 17% |
Agricultural and Biological Sciences | 254 | 10% |
Engineering | 106 | 4% |
Chemistry | 83 | 3% |
Other | 300 | 12% |
Unknown | 751 | 30% |