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Detection and localization of surgically resectable cancers with a multi-analyte blood test

Overview of attention for article published in Science, January 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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1921 Dimensions

Readers on

mendeley
2521 Mendeley
citeulike
2 CiteULike
Title
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Published in
Science, January 2018
DOI 10.1126/science.aar3247
Pubmed ID
Authors

Joshua D Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Ludmila Danilova, Christopher Douville, Ammar A Javed, Fay Wong, Austin Mattox, Ralph H Hruban, Christopher L Wolfgang, Michael G Goggins, Marco Dal Molin, Tian-Li Wang, Richard Roden, Alison P Klein, Janine Ptak, Lisa Dobbyn, Joy Schaefer, Natalie Silliman, Maria Popoli, Joshua T Vogelstein, James D Browne, Robert E Schoen, Randall E Brand, Jeanne Tie, Peter Gibbs, Hui-Li Wong, Aaron S Mansfield, Jin Jen, Samir M Hanash, Massimo Falconi, Peter J Allen, Shibin Zhou, Chetan Bettegowda, Luis A Diaz, Cristian Tomasetti, Kenneth W Kinzler, Bert Vogelstein, Anne Marie Lennon, Nickolas Papadopoulos

Abstract

Earlier detection is key to reducing cancer deaths. Here we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1,005 patients with non-metastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69% to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was > 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 1,272 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2,521 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2521 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 495 20%
Student > Ph. D. Student 384 15%
Student > Master 216 9%
Student > Bachelor 210 8%
Other 171 7%
Other 408 16%
Unknown 637 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 593 24%
Medicine and Dentistry 434 17%
Agricultural and Biological Sciences 254 10%
Engineering 106 4%
Chemistry 83 3%
Other 300 12%
Unknown 751 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3428. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#1,693
of 25,559,053 outputs
Outputs from Science
#99
of 83,115 outputs
Outputs of similar age
#14
of 452,396 outputs
Outputs of similar age from Science
#3
of 1,186 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,115 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,396 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,186 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.